IRRAS’ IRRAflow[®] System Demonstrates Ability to Treat Pyogenic Ventriculitis through Targeted Delivery of Antibiotics in Case Series Published in Neurosurgery Open

Stockholm, September 29, 2021 – IRRAS, a global medical technology company with a comprehensive portfolio of innovative products for neurocritical care, today announced the publication of a case series in the Neurosurgery Open medical journal that demonstrates the ability of its IRRAflow system to treat aggressive brain infections by delivering needed antibiotics directly to the infection site.  The published patient treatments were performed by Dr. Behnam Rezai Jahromi at Helsinki University Hospital (HUH), one of the world’s leading hospitals for neurosurgical treatment.

The case series documents the survival of two patients that were diagnosed with pyogenic ventriculitis, a rare and debilitating infection of the lining of the ventricles in the brain that store cerebrospinal fluid (CSF).  Patients suffering from such infections face mortality and long-term disability rates of 60% and 80%, respectively.  Typically, ventriculitis is treated with long-term treatment of IV antibiotics, but the blood-brain barrier (BBB) makes it difficult for such drugs to reach therapeutic levels in the brain.

In the case series, Dr. Rezai Jahromi concluded that, with IRRAflow treatment, “the drainage of purulent fluid caused by healthcare associated ventriculitis or meningitis is now possible without harming brain tissue and intracranial pressure (ICP), while also changing the composition of CSF to an antibiotic-consisted fluid.”

This published case series is the first deliverable from the previously announced long-term collaboration between IRRAS and the neurosurgery team from Helsinki University.  HUH Neurosurgery is world-famous for its expertise in all subsections of neurosurgery and is considered one of the leading centers in Europe in the microneurosurgical treatment of cerebral blood vessel diseases and complex brain tumors.  Each year, more than 3,200 patients undergo neurosurgical treatment at Helsinki, and nearly 200 neurosurgeons from all around the world visit the facility to learn the latest techniques in neurosurgery.  

“Previously, leading neurosurgeons published their successful experience of delivering drugs that reduce spasm or prevent blood clot formation using IRRAflow’s irrigation,” said Will Martin, President and Chief Executive Officer.  “This case series is the first time that IRRAflow’s ability to irrigate with antibiotics has been documented in scientific literature, and it further validates the versatility of IRRAflow in treating a wide range of intracranial pathologies.  These critically ill patients have historically experienced extremely poor life expectancy, and we are pleased that IRRAflow may provide an option to improve their prognosis.”

With this case series now published, IRRAS’ partnership with HUH will now focus upon the ability to treat patients with intraventricular hemorrhage (IVH) with IRRAflow by irrigating thrombolytic medication to enhance clot removal.  Dr. Rezai Jahromi will present his IVH treatment experience with IRRAflow in a poster presentation at the upcoming Congress of Neurosurgical Surgeons (CNS) annual meeting in Austin, TX, from October 16 -20, 2021, and he will also serve as the Primary Investigator (PI) in the upcoming ARCH clinical study that will study IVH treatment using IRRAflow to irrigate thrombolytic medication.

A link to the publication, “Active Cerebrospinal Fluid Exchange System for Treatment of Pyogenic Ventriculitis,” can be found here:


IRRAS is a global medical care company focused on delivering innovative medical solutions to improve the lives of critically ill patients. IRRAS designs, develops, and commercializes neurocritical care products that transform patient outcomes and decrease the overall cost of care by addressing complications associated with current treatment methodologies. IRRAS markets and sells its comprehensive, innovative IRRAflow and Hummingbird ICP Monitoring product lines to hospitals worldwide through its direct sales organization in the United States and select European countries as well as an international network of distribution partners.  

IRRAS maintains its headquarters in Stockholm, Sweden, with corporate offices in Munich, Germany, and San Diego, California, USA. For more information, please visit 

IRRAS is listed on Nasdaq Stockholm (ticker: IRRAS). 

For more information, please contact: 

Will Martin
President and CEO 

Sten Gustafsson
Director, Investor Relations
+46 102 11 5172 


The information was released for public disclosure, through the agency of the contact person above, on September 29, 2021 at 08:30 (CET). 

Irras Radio Irras Academy

At IRRAS, your privacy and the protection of your personal data are important to us. To ensure GDPR compliance, this website does not store or track any personal information, including Google Analytics or form submission data.
By using the website, you acknowledge and accept our policy.